Game Preview

San Francisco 49ers vs Washington Commanders Pick and Preview

Christian Mccaffrey

NFC Conference Matchup

Point Spread: 49ers -12.5 | Total Points: 49.5

Coming into this week’s NFC matchup vs the Commanders, the 49ers have an above .500 record at 11-4. The 49ers recently suffered a 33-19 defeat at the hands of the Ravens. Besides their loss in the game, the 49ers couldn’t cover the spread despite being 6.5-point favorites. The team, in conjunction with Baltimore, combined for 52 points, surpassing the over/under line of 46.5.

This week, the Commanders will look to snap their current six-game losing streak with a victory over the 49ers. Heading into action, the team has a below .500 record of 4-11. After a 30-28 loss to the Jets, the Commanders are looking to get back on track this week. Despite their defeat against New York, the Commanders managed to cover the spread as 3-point underdogs in that game. With a combined score of 58 points, the game exceeded the pre-game over/under line of 36.5.

San Francisco 49ers vs Washington Commanders History

In their only head-to-head matchup last season, the 49ers won by a score of 37-20. The over/under line in last year’s matchup between the 49ers and Commanders was 37.5, which they surpassed with 57 points combined. The 49ers finished with the ATS win in this game. Offensively, the 49ers finished with 371 total yards, with 218 coming in the passing game and 153 on the ground. The Commanders finished with 349 yards of offense in the loss.

The last three times the 49ers have traveled to take on the Commanders, they are 2-1. The last three times that the Commanders have hosted the 49ers, the over/under record is 1-2, with the teams combining for an average of 30 points. The over/under record in their last three overall matchups is 1-2.

Notable Injuries

San Francisco 49ers

  • Jaylon Moore – Concussion (Questionable)
  • Talanoa Hufanga – Knee (Out)
  • Elijah Mitchell – Knee (Probable)
  • Jauan Jennings – Concussion (Questionable)
  • Ross Dwelley – Ankle (Questionable)
  • George Odum – Bicep (Out)
  • Arik Armstead – Foot/knee (Questionable)
  • Trent Williams – Groin (Questionable)
  • Oren Burks – Knee (Questionable)
  • Ray-Ray McCloud III – Rib (Out)
  • Cameron Latu – Knee (Out)
  • Brock Purdy – Left Shoulder (Probable)
  • Drake Jackson – Knee (Out)
  • Nick Zakelj – Bicep (Out)
  • Danny Gray – Shoulder (Questionable)
  • Kalia Davis – Ankle (Out)
  • Aaron Banks – Toe (Questionable)
  • Ambry Thomas – Knee/hand (Questionable)
  • Ji’ayir Brown – Knee (Questionable)
  • Javon Hargrave – Hamstring (Questionable)
  • Deebo Samuel – Neck (Questionable)

Washington Commanders

  • David Mayo – Knee (Probable)
  • John Ridgeway III – Foot (Questionable)
  • Percy Butler – Wrist (Questionable)
  • Curtis Brooks – Undisclosed (Out)
  • Curtis Hodges – Back (Out)
  • Brian Robinson Jr. – Hamstring (Questionable)
  • Chris Rodriguez Jr. – Foot (Out)
  • Ricky Stromberg – Knee (Out)
  • Braeden Daniels – Shoulder (Out)
  • Armani Rogers – Achilles (Out)
  • Dax Milne – Groin (Out)
  • Shaka Toney – Suspension (Out)
  • Benjamin St-Juste – Concussion (Questionable)
  • Jamin Davis – Shoulder (Out)
  • Darrick Forrest – Shoulder (Out)
  • David Bada – Triceps (Out)
  • Jeremy Reaves – Knee (Out)
  • Andrew Wylie – Elbow (Questionable)
  • Efe Obada – Leg (Out)
  • Charles Leno Jr. – Calf (Questionable)
  • Tyler Larsen – Knee (Questionable)

Keys To Victory: San Francisco 49ers

If the 49ers are going to come away with a win, they will yet again rely on an offense that is averaging 29.6 points per game. This season, San Francisco’s passing offense ranks 28th in passing attempts. With an average of 265.7 passing yards per game, they hold the 2nd spot in the NFL. This season, the 49ers offense is handing the ball off at one of the higher rates in the NFL. This has translated to an average of 28.7 yards per game, placing them 4th in the NFL.

Keys To Victory: Washington Commanders

In this week’s game vs the 49ers, the Commanders will be turning to Jacoby Brissett in what will be his first start of the season. Overall, he has played in three games and thrown for 224 yards this year. Heading into the game, the team’s top receiver Terry McLaurin who through 15 games has 885 receiving yards this season. Offensively, the Commanders would benefit from sticking to the run, as they are one of the more efficient units on a per carry basis. However, they are ranked just 21st in rush yards per game.

Betting Trends

  • In their last ten games away from home, the 49ers have a straight-up record of 7-3 while going 5-4-1 vs. the spread. The team averaged 29 points per game in this stretch.
  • In their last five home games, Washington has averaged 20 points per game while allowing 29. The team’s record in this stretch was 1-4 while going 3-2.
  • In their last five games as the betting underdog, the Commanders have a straight-up record of 0-5 and an ATS mark of 2-3.
  • Looking back on the team’s last ten games as the favorite, the 49ers have a straight up record of 6-4. Their record vs the spread in these games was 4-6.


  • San Francisco 49ers 27 – Washington Commanders 21
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