Game Preview

San Francisco 49ers vs Philadelphia Eagles Pick and Preview

DeVonta Smith

NFC Conference Matchup

Point Spread: 49ers -3 | Total Points: 47.5

Overall, the 49ers have an above .500 record at 8-3. Helping their cause is the fact that they are in the midst of a three game winning streak. In NFC action, the team is 6-1. The 49ers played on the road vs. the Seahawks in week 12, winning by a score of 31-13. The 49ers were able to cover the spread vs. Seattle, as they went into the game favored by 7. The over/under line for the game was 43 points, and the teams managed to surpass it, recording a combined total of 44 points.

Coming into this week 13 NFC matchup, the Eagles are in the middle of a five-game winning streak and have an above .500 record of 10-1. The Eagles recently secured a victory, defeating the Bills with a final score of 37-34. Given that they were favored by 2.5 against the Bills, the Eagles picked up an ATS win. Going into the game, the over/under line was 48.5 points with Buffalo; the team’s performance exceeded the over/under line of 71.

San Francisco 49ers vs Philadelphia Eagles History

In their only head-to-head matchup last season, the Eagles won by a score of 31-7. In their only head-to-head matchup, the teams scored 38 points, which fell below the over/under line of 44.5. The Eagles covered the spread in last year’s matchup. In last year’s win, the Eagles finished with 269 of total offense, with 148 coming in the running game and 121 through the air. On the other side, the 49ers ended the game with 164 yards of offense.

When looking back on the last three head-to-head matchups between San Francisco and Philadelphia, the Eagles hold the edge with a record of 2-1. Not only does the team have the better record, but they have won in convincing fashion, posting an average scoring differential of 8 points.

Notable Injuries

San Francisco 49ers

  • George Odum – Bicep (Out)
  • Drake Jackson – Knee (Out)
  • Talanoa Hufanga – Knee (Out)
  • Danny Gray – Shoulder (Out)
  • Spencer Burford – Knee (Questionable)
  • Nick Zakelj – Bicep (Out)
  • Cameron Latu – Knee (Out)
  • Arik Armstead – Foot (Questionable)
  • Ray-Ray McCloud III – Rib (Questionable)
  • Jordan Mason – Hamstring (Questionable)

Philadelphia Eagles

  • A.J. Brown – Thigh (Questionable)
  • D’Andre Swift – Ankle (Probable)
  • DeVonta Smith – Knee (Probable)
  • Julio Jones – Knee (Questionable)
  • Shaun Bradley – Achilles (Out)
  • Isaiah Rodgers Sr. – Suspension (Out)
  • Milton Williams – Concussion (Probable)
  • Nakobe Dean – Foot (Out)
  • Jordan Davis – Hamstring (Questionable)
  • Grant Calcaterra – Ankle (Questionable)
  • Roderick Johnson – Undisclosed (Out)
  • Dallas Goedert – Forearm (Questionable)
  • Avonte Maddox – Pectoral (Out)
  • Justin Evans – Knee (Questionable)
  • Zach Cunningham – Hamstring (Questionable)
  • Fletcher Cox – Groin (Questionable)
  • Lane Johnson – Groin (Probable)

Keys To Victory: San Francisco 49ers

This year, the 49ers offense has looked good, averaging 28.2 points per game, placing them 3rd when compared to other NFL teams. San Francisco’s passing offense enters this week’s game with a ranking of 8th in passing yards. Furthermore, they hold the 30th spot in attempts, averaging 28.1 passes per game. San Francisco comes into the game with one of the better rush attacks in the NFL, averaging 4.4 yards per attempt. This strong figure has led to the team ranking 7th in yards per game on the ground.

Keys To Victory: Philadelphia Eagles

The Eagles come in with an average of 28.2 points per game, which is 3rd in the NFL. Jalen Hurts holds a passer rating of 94.9, which is 17th among quarterbacks. This has come while throwing for 2697 yards and recording 18 passing touchdowns. Philadelphia comes into the game with one of the better rush attacks in the NFL, averaging 4.1 yards per attempt. This strong figure has led to the team ranking 8th in yards per game on the ground.

Betting Trends

  • In their last five games away from home, the 49ers have a straight-up record of 3-2 while going 2-2-1 vs the spread. The team averaged 25 points per game in this stretch.
  • Across their last five home contests, Philadelphia has been good against the spread, posting a mark of 3-1-1. Their overall mark in these games was 4-1, while averaging 24 points per game.
  • Going back to their previous ten games as the underdog, Philadelphia has an ATS mark of 3-7 while going 2-8 straight up.
  • As the betting favorite, the 49ers have an ATS record of 2-1 in their last three games. In these matchups, their straight up record was 3-0.


  • Philadelphia Eagles 27 – San Francisco 49ers 26
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