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San Francisco 49ers vs Arizona Cardinals Pick and Preview

deebo samuel

NFC West Divisional Matchup

Point Spread: 49ers -12 | Total Points: 47.5

Overall, the 49ers have an above .500 record at 10-3. Helping their cause is the fact that they are in the midst of a five-game winning streak. In NFC action, the team is 8-1. The 49ers came out on top in their previous game against the Seahawks, with the game ending in a score of 28-16. On the point spread, the 49ers were favored by 14.5 against the Seahawks. Even though they won by 12, it was not enough to cover. In their most recent game, the over/under line was 44.5 points. By combining for 44 points, the under hit.

Coming into this week’s NFC matchup vs the 49ers, the Cardinals have a below .500 record at 3-10. In their previous game, the Cardinals secured a victory against the Steelers by a score of 24-10. Besides their outright victory, the Cardinals also covered the spread as 6-point underdogs. The under hit in the Cardinals’ most recent game, as the teams combined for 34 points. The line going into the game was 41.

San Francisco 49ers vs Arizona Cardinals History

In their two head-to-head matchups last season, the 49ers went 2-0. The over/under under mark in these matchups was 2-0, with the teams combining to average 49.5 points per contest. When looking at the spread, the 49ers went 2-0 in their head-to-head matchups. In these head-to-head matchups, the 49ers’ offense averaged 349 yards per game compared to the Cardinals at 284.5.

Over their previous five games against the Cardinals, the 49ers have put together a record of 3-2. Looking back at the last three times the 49ers took on the Cardinals as the betting favorite, they have gone a perfect 3-0 vs. the spread on an average scoring differential of 24.

Notable Injuries

San Francisco 49ers

  • Oren Burks – Knee (Doubtful)
  • Dre Greenlaw – Hip/ankle (Questionable)
  • George Odum – Bicep (Out)
  • Ray-Ray McCloud III – Rib (Out)
  • Charvarius Ward – Groin (Questionable)
  • Ross Dwelley – Ankle (Out)
  • Javon Hargrave – Hamstring (Questionable)
  • Arik Armstead – Foot/knee (Questionable)
  • Talanoa Hufanga – Knee (Out)
  • Elijah Mitchell – Knee (Questionable)
  • Drake Jackson – Knee (Out)
  • Aaron Banks – Hip (Questionable)
  • Danny Gray – Shoulder (Out)
  • Nick Zakelj – Bicep (Out)
  • Spencer Burford – Knee (Questionable)
  • Cameron Latu – Knee (Out)

Arizona Cardinals

  • Antonio Hamilton Sr. – Groin (Questionable)
  • Pat Elflein – Hip (Out)
  • Marlon Mack – Achilles (Out)
  • Carlos Watkins – Bicep (Out)
  • Elijah Wilkinson – Neck (Questionable)
  • Kyzir White – Biceps (Out)
  • Rashad Fenton – Undisclosed (Out)
  • L.J. Collier – Bicep (Out)
  • Marquise Brown – Heel (Questionable)
  • Leki Fotu – Hand (Out)
  • Bobby Price – Quad (Questionable)
  • Hayden Howerton – Undisclosed (Out)
  • Michael Wilson – Neck (Questionable)
  • Jon Gaines II – Knee (Out)
  • Starling Thomas V – Ankle (Questionable)
  • Emari Demercado – Neck (Questionable)
  • Matt Hembrough – Back (Out)
  • Geoff Swaim – Back (Questionable)
  • Kevin Strong – Knee (Questionable)
  • Jalen Thompson – Toe (Questionable)
  • Krys Barnes – Ribs (Questionable)
  • Blake Gillikin – Back (Questionable)

Keys To Victory: San Francisco 49ers

On offense, the 49ers have been one of the better teams in the league in the first quarter, ranking 6th in the NFL. Overall, they are averaging 29.2 points per game (3rd). A strength of this year’s team has been their offensive line, as they have only allowed sacks on 6.7% of the team’s passing attempts. This strong protection has helped the team average 262.7 yards per game through the air. At 139.6 rushing yards per game, the 49ers are currently ranked 3rd in the NFL. In terms of attempts, they are carrying the ball an average of 29.8 times per game which is 6th.

Keys To Victory: Arizona Cardinals

The Arizona offense comes into week 15, averaging only 17.7 points per game, placing them 24th in the league. Looking at their passing game, the Cardinals come in with an average of 172.4 passing yards per game, which is 30th in the league. Presently, 53% of their first downs are credited to the passing game. If the Arizona offense is going to improve their overall scoring numbers, they should look to run the ball more frequently. This year, they are a below-average unit in rush attempts per game but are still producing at a rate of 123.9 yards per contest.

Betting Trends

  • When looking at their past three road matchups, San Francisco has an ATS record of 3-0 while averaging 35 per game. The team went 3-0 overall in these games.
  • In their last five games at home, the Cardinals have a straight-up record of 1-4 while going 2-3 vs. the spread. The team averaged 11 points per game in this stretch.
  • Spanning across their last five games as the betting underdog, the Cardinals have gone 3-2 vs the spread. Their overall record in these games was 2-3.
  • Looking back on the team’s last ten games as the favorite, the 49ers have a straight-up record of 7-3. Their record vs the spread in these games was 5-5.


  • San Francisco 49ers 26 – Arizona Cardinals 23
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